Info Tentang 10-HDA Yang Terkandung Dalam Susu Lebah

Info 10-HDA

1O-hydroxy-2-decenoic acid

General Description

Product Name: 10-hydroxy-2-decenoic acid
Synonyms: Royal Jelly Acid, 10-HDA
10-hydroxy-delta 2-decenoic acid,
(E)-1 0-hydroxy-2-decenoic acid
Trans 10-hydroxy- 2-decenoic acid

Molecular Structure:

Molecular Formula: C10H1803
CAS: 14113-05-4
Molecular Weight: 186.25

Brief introduction:

10-Hydroxy-2-Decenoic Acid is a kind of special active substance which exists only in royal jelly in the nature. It is also called 10-HDA or royal jelly acid. The content of 10-HDA in royal jelly is usually around 1.5%-2,0%. Since it has the function of anticancer, skin care and Antibacterial effect etc,, it can be added to health food or cosmetics as an active ingredient. The content of 10-FIDA in royal jelly is the international standard of the quality of royal jelly and it directly determines the price of royal jelly on the international market.

Function

(1) 10-HDA possesses strong inhibition to the growth of cancer cells, namely transferable AKR Leukaemia, TA3 breast cancer etc. Recent studies show that i O-HDA possesses the effect of immuno-regulation and anti-cancer activities.3,5,6,7,8

10-HDA’s strong cancer fighting properties were first witnessed by a study published in Nature in May 1959. The scientists mixed 10-HDA with active tumour cells taken from cancerous mice. They report that an injection of the mixture suppressed mouse leukaemia and inhibited the formation of tumours.

These results have been confirmed repeatedly on nearly 1000 mice during a two-year period and show a striking effect: either all the mice die quickly, or all survive. Two groups of mice which received tumour cells plus 10-HDA remained alive and healthy more than 12 months after inoculation, while sister mice which received the same number of tumour cells without l0—HDA died within 12 days.

In other words, the scientists carne up with a vaccine that protects mice against leukaemia and the subsequent development of related tumours.

(2) 10-HDA has a strong Antibacterial property 2,9,10

(3) 10-HDA has skin care, skin whitening and antioxidative activity effect 4,11,12,13

(4) 10-HDA prevents the bss of Leukocyte during the chemical treatment.

(5) 10-HDA has Other function including treatment of AIDS and other immunodeficiency diseases14, insulin-like effect for diabetes and Hypertension 15,16, Antiulcer effects17 and preventive and therapeutic effectson hyperlipoidemia18.

Specification

ANALYSIS ITEM	SPECIFICATION	METHOD
Appearance	White to Yellow crystalline powder	Visual
Assay	98%	HPLC
Melting point	64 °C
Water (KF)	<= 0.2%
Heavy Metals	< 10 ppm	USP27
Pb	< 0.5 ppm
Hg	< 0.05 ppm
As	< 0.1 ppm
Cr	< 0.1 ppm
Residual Solvents	Eur. Pharm. 2000
Total Plate Count	< 1000 cfu/g
E. Coli	Negative/g	Ph. Eur 2.6.13
Coliforms	<10 cfu/g	Ph. Eur 2.6.13
Staphylococcal	Negative /10g	Ph. Eur 2.6.13
Salmonella	Negative /25g	Ph. Eur 2.6.13
Yeasts and moulds	< 300 cfu/g	Ph. Eur 2.6.13

Reference

[1] TOWNSEND, GF., MORGAN, J.F., HAZLETT, B. Activity of 10-hydroxydecenoic acid from Royal Jelly against experimental leukaemia and ascitic tumours. Nature, v. 183, n. 4670, p. 1270-1271, 1959.

[2] Blum, Murray S.; Novak, Arthur F.; Taber, Stephen, 10-Hydroxy-2-decenoic acid, an antibiotic found in royal jelly., Science (1959), 130 452-3.

[3] Townsend, Gordon F.; Morgan, Joseph F.; Toinai, Susan; Hazlett, Barbara; Morton, Helen J.; Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly. Cancer Research (1960), 20 503-10.

[4] Satomi, Koya-Miyata; Okamoto, Iwao; Ushio, Shimpei; Iwaki, Kanso; Ikeda, Masao; Kurimoto, Masashi. Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Bioscience, Biotechnology, and Biochemistry (2004), 68(4), 767-773.

[5] Wang, Y.; Kandeler, R. Botanisches. Promotion of flowering by a tumour promoter. Journal of Plant Physiology (1994), 144(6), 710-13.

[6] Wang, Guoyan; Lin, Zhibin. Antitumor and immunopotentiating effect of 10-hydroxy-2-decenoic acid on tumor-bearing mice. Beijing Yike Daxue Xuebao (1996), 28(5), 33 1-333.

[7] Wang, Guo-Yan; Lin, Zhi-Bin. Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro. Zhongguo Yaoli Xuebao (1997), 18(2), 180-182.

[8] Wang, Guoyan; Lin, Zhibin. Effects of 10-hydroxy-2-decenoic acid on T lymphocyte and its subtypes and interleukin 2 production in mice. Zhongguo Yaolixue Yu Dulixue Zazhi (1996), 10(1), 53-55.

[9] Pollet, S.; Bottex-Gauthier, C.; Li, M.; Potier, P.; Favier, A.; Vidal, D. Insight into some of the signalling pathways triggered by a lipid immunomodulator Immunopharmacology and Immunotoxicology (2002), 24(4), 527-546.

[10] Yatsunami, Kazuhisa; Echigo, Takashi. Tamagawa Nogakubu Antibacterial action of royal jelly. Kenkyu Hokoku (1985), (25), 13-22.

[11] Miyata, Satomi; Okamoto, Iwao; Ushio, Shimpei; Kurimoto, Masashi. Collagen production enhancer and production process and use thereof. PCT mt.Appi. (2005), 34 pp.

[12] Takimoto, Hiroyuki; Motoyoshi, Katsuhiro. Skin or hair cosmetics. Kokai Tokkyo Koho (1998), 8 pp.

[13] Matsugami, Michio; Horikoshi, Haruyo; Kimura, Tomoshi; Koiso, Ichiro; Ochiai, Michio. Skin-whitening cosmetics. Kokai Tokkyo Koho (1986), 5 pp.

[14] Use ofan iron-binding glycoprotein and/or 10-hydroxy-2-decenoic acid in combination with thymoquinone for the treatrnent ofAIDS and other immunodeficiency diseases. Mekkawi, Sherif Sabry Ragab. (Egypt). Ger. (2000), 4 pp.

[15] Okuda, Hiromichi; Kameda, Kenji; Morimoto, Chie; Matsuura, Yukinaga; Chikaki, Mariko; Jiang, Ming. Studies on insulin-like substances and inhibitory substances toward angiotensin-converting enzyme in royal jelly. Mitsubachi Kagaku (1998), 19(1), 9-14.

[16] Karneda, Kenji; Chikaki, Mariko; Morimoto, Chie; Jiang, Ming; Okuda, Hiromichi. Insulin-like actions oftrans-10-hydroxy-2-decanoic acid and its related substances. Wakan Iyakugakii Zasshi (1996), 13(4), 456-457.

[17] Fang, Erli; Zhou, Huazhu; Xu, Hongli; Xing, Meijuan. Antiulcer effects of 10-hydroxy-2-decenoic acid in rats. Zhongguo Yaolixue Tongbao (1994), 10(2), 13 9-42.

[18] Xu Donghui; Mei Xueting; Xu Shibo The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat. Journal of Chinese medicinal materials (2002), 25(5), 346-7.

 

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